PhD spatial proteomics

Are you an ambitious researcher with a background in neuroscience or biomolecular science? As a PhD _tudent in our team, you will investigate how cell-type vulnerability or resilience impact neurodegeneration in the human brain using innovative proteomics other -omics techniques. Frontotemporal dementia (FTD) encompasses a group of neurodegenerative diseases that progressively affect behavior, movement, personality and/or language. We aim to identify the molecular and cellular causes of FTD that trigger its onset and early progression with the aim to design evidence-based treatment. We are looking for a highly motivated researcher to join our team. You will design and execute proteomics studies on human brain tissue of sporadic patients and human iPSC-derived neurons. The aim is to understand the molecular and cellular dysfunctions that lead to cell-type-specific vulnerability that may be causative to FTD through highly innovative single-cell and spatial (prote)-omics technologies. Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page. As a member of our team, you will: design and execute proteomics studies to identify cell-type specific vulnerability; perform experiments in human postmortem FTD brain tissue and patient iPSC-derived neuronal cell cultures; aid in data analysis and integration of -omics datasets to characterize cell-specific functional dysregulation and cellular crosstalk; contribute to scientific reporting, publications, and regulatory-ready data packages; supervise undergraduate _tudents; report on your findings in regular work meetings, conferences, and scientific publications in reputable journals. This position offers a unique opportunity to contribute to translational neuroscience in a dynamic team of proteomic and neuroscience researchers in the search for fun_amental insights with real-world therapeutic impact. You have: a master's degree in neuroscience, biomolecularscience, or biochemistry; proven expertise and skills with molecular and cellular work as part of an internship; experience with programming and data analysis (Python, R). Expertise with omics datasets is a strong advantage; strong written and verbal communication skills in English. We are looking for the following personality traits: excellent organisational and management skills; working diligently and with high accuracy; a team player who enjoys collaborating in an interdisciplinary environment; a...

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