PhD Student (m/f/d) 13914 / Brückeninstitut für Experimentelle Tumorforschung (BIT) (Wissenschaftliche/r Mitarbeiter/in)

Work Area: Institute for Experimental Tumour Therapy Job ID: 13914 Start Date: Next possible date Work Scope: Parttime (25,025 hours per week) Contract Type: Temporary contract Contract duration: 30. June 2030; in accordance with § 2 (2) WissZeitVG for the duration of the project Your tasks: Opportunity to conduct high-level interdisciplinary research within the newly established DFG funded Collaborative Research Centre CRC/SFB 1752 “DYNAMO”, investigating the earliest mechanisms of therapy resistance in melanoma during the first days and weeks after therapy initiation: • Work in Project B01 • Deciphering fibroblast heterogeneity and its implications for immune checkpoint inhibitor response in melanoma • Investigation of fibroblasts, melanoma, and T cell interactions in the context of immune checkpoint inhibitor (ICI) response and resistance in melanoma • Multiplex imaging and spatial characterization of tumor–immune interactions • Contribution to experimental design and execution of immune-oncology focused and in vitro and ex vivo functional assays • Gene expression analyses (e.g. qPCR) and cytokine/chemokine profiling in tumor immune interaction models • Data analysis, interpretation, and integration of experimental results in collaboration with computational project partners • Participation in presentation of scientific results at meetings and conferences Your profile: • Completed Diploma or Master degree in molecular biology or cancer biology, immunology, cell biology, bioinformatics, translational medicine or related disciplines • Strong interest in melanoma biology, tumor immunology, immune checkpoint therapy, translational cancer research, and tumor–immune interactions • Strong interest in multiplex/spatial imaging approaches (e.g. Phenocycler or related platforms) • Experience in molecular and cellular biology techniques • Experience with cell culture, cytokine profiling, flow cytometry and/or microscopy is desirable • Experience with bioinformatics or biostatistics is advantageous • Ability to work independently and in interdisciplinary teams, specifically bridging melanoma biology and tumor immunology • Ability to work closely with the second B01 project team and contribute to active scientific exchange • High level of self-motivation, scientific curiosity, reliability, personal initiative, creativity, and team-oriented personality • Enthusiasm for hands-on experimental and computational research and active contribution to a dynamic,...

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