Postdoc

Postdoc: Antigen-specific single-cell profiling Bilthoven - route • Op locatie • Overheid & Non-Profit €3.496 - €5.535 / mnd 32 - 36 uur/week Tijdelijk contract Geen specifiek diploma vereist Medior (2-5 jaar) Deze vacature is overgenomen van een externe bron. Een helder overzicht van de functie, werkomgeving en belangrijke details. Dit ga je doen Can we distinct short- and long-term cellular immunity in order to improve vaccination strategies? In this position at RIVM you will contribute to public health by generating and analyzing single-cell datasets for exploring why longevity of cellular immunity induced by different vaccines and pathogens differs. You will have access to unique clinical cohorts, cutting-edge flow cytometry and sequencing technologies, and dedicated bioinformatic support. This two-year post offers a collaborative, research-focused environment where your daily laboratory work shapes meaningful scientific insights. Understanding the mechanisms behind why cell-mediated immunity lasts for decades after certain infections or vaccines, while fading quickly after others, is crucial for designing next-generation public health strategies. In this two-year position you address this question by mapping antigen-specific B and T cell responses at single-cell resolution. Your primary focus is the hands-on generation and analysis of single-cell datasets from clinical cohorts. Working within a dedicated project team, you profile cellular immune responses triggered by various pathogens and vaccines to evaluate both the depth and longevity of protection. You work closely alongside an experienced bioinformatician to integrate, interpret, and translate complex laboratory data into immunological insights. Your key tasks include: By generating these high-dimensional single-cell datasets, you help uncover the biological determinants of durable immunity, offering evidence that can refine future vaccination frameworks. Beyo...

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